Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide
نویسندگان
چکیده
منابع مشابه
Effect of Fatty Acid Conjugation on Antimicrobial Peptide Activity
Two peptides, YGAA[KKAAKAA]2 (AKK), and YG[AKAKAAKA]2 (KAK) were conjugated to fatty acids and tested for the effect on their structure, antibacterial activity, and eukaryotic cell toxicity. In the presence of bacteria-mimicking phospholipid vesicles fatty acid conjugates of the amphipathic peptide, AKK, show a larger change in helical structure than either of the unmodified peptides or the con...
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Three peptides, YGAA[KKAAKAA](2) (AKK), KLFKRHLKWKII (SC4), and YG[AKAKAAKA](2) (KAK), were conjugated with lauric acid and tested for the effect on their structure, antibacterial activity, and eukaryotic cell toxicity. The conjugated AKK and SC4 peptides showed increased antimicrobial activity relative to unconjugated peptides, but the conjugated KAK peptide did not. The circular dichroism spe...
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ژورنال
عنوان ژورنال: Engineering
سال: 2015
ISSN: 2095-8099
DOI: 10.15302/j-eng-2015106